Pilot We meet April at a pivotal moment in her life: she's landed a fantastic opportunity to impress her hard-nosed Boston newspaper editor and an office romance with her super-sexy co-worker Dominic is just beginning to blossom. In an unexpected twist of fate, April lands in the hospital where her estranged uncle, George, works as an oncologist, and she learns the devastating news that she has cancer.
Help Wanted As April learns more about her cancer and prospective treatment, she is determined not to let it affect her progress at work. A new assignment to profile gubernatorial candidate Bruce Hendrie leads to an unexpected run-in with his son, Leo. April also makes a startling discovery about her family. Meanwhile, Sara makes progress with her online dating but struggles with solo parenting when she learns Brenna lied about her "extra-curricular" activities.
Blood Cancer Sex Carrots As things begin to heat up with Dominic, April second-guesses the status of their relationship when she learns he has a reputation as the office playboy. To help take her mind off of Dominic and to start facing the reality of her symptoms, she volunteers for an assignment at work about a supposed cancer-curing miracle juice and finds a confidant and support in the juice maker, Gerald. Meanwhile, Sara makes a surprise connection with one of her therapy patients and hosts an awkward dinner for her new boyfriend, Ben, to meet the family.
I'll Sleep When I'm Dead April finds it harder to juggle the increasing severity of her symptoms with her obligations at work and her attempts to be a supportive daughter and sister. After missing an important appointment, George urges April to get her priorities straight. April also learns more about Leo Hendrie, but Leo jumps to conclusions about April's motives. Meanwhile, much to her own surprise, Brenna bonds with Greer, a popular girl at school.
The Family That Lies Together Dominic takes April to see a psychic for fun, but the results disturb both of them, leading Dominic to come clean to April about a family secret. When her own family secrets become too much for her to bear alone, April enlists Dominic's help in learning more about her "sister," Natalie. Meanwhile, April receives an official diagnosis from George and Sara's mounting concern for April's health leads to a confrontation.
Clear Minds, Full Lives, Can't Eat! April gets a surprising invite to shadow Bruce Hendrie at his campaign ad shoot for the paper. While there, Leo senses her apprehension of her diagnosis and challenges April to take control of her future. Not one to back down from a challenge, April accepts and gets a taste of Leo's reckless and carefree life. But when things go too far, she learns the severity of Leo's illness. Meanwhile, Brenna is unsure of her future with Kiernan, even more so when the relationship causes tension with her new friend Greer.
Unplanned Parenthood April sees a fertility doctor to learn about her options prior to starting chemotherapy and looks to her cancer support group for advice on how to tell Dominic about her leukemia. She gets Leo's blessing to write a piece that paints Bruce Hendrie in an unflattering light and wins some hard-earned recognition at work. Meanwhile, George makes an effort to help Sara cope with her emotions and the pressure of caring for April, and Dominic gets a surprising offer which could change everything.
Death Becomes Her When a friend and fellow member of her support group faces a worsening prognosis, April begins to think more about death and her own mortality. She blows off a nightmare assignment to play hooky from work with Beth and other members of the support group and learns something surprisingly endearing about Leo. Meanwhile, Brenna travels to Miami on a school trip and uses the opportunity to meet Natalie with Greer's help.
What To Expect When You're Expecting Chemo With only a few days left before April has to check herself into the hospital for aggressive chemotherapy, April is determined to live as normal a life as ever. But as she has to deal with Leo drama, Beth falling apart, and trying to live under the hovering eye of Sarah, April quickly learns that nothing will ever be "normal" for her. Meanwhile, Brenna tries to juggle time with Kieran and Greer.
Finding Chemo April begins her battle and month-long hospital stay with mixed emotions. Her resolve to fight starts to wane as her treatments take a toll. Not sure she can be cooped up in the hospital for much longer, April begins to panic. With her family by her side, April makes a surprising outreach to someone who may be the only person who can help her. Meanwhile, Dominic returns to a much different April then when he left.
Locks Of Love when they pay a visit, and the Carvers celebrate an early family Christmas. The full contents of Leo's cryptic voicemail are revealed, leading April and Leo to rethink their last goodbye. In an attempt to help her friend cope with the effects of chemo, Beth helps April with a makeover, or two.
Next April After leaving Leo flat-lining at the end of the Christmas episode, April must deal with the outcome of the surgery. Facing her new reality, she must also face her first day back at work after being gone for four months. In remission and determined to move on with her life, her return reveals a new, young and ambitious boss at the paper who is ready to shake things up. But April's attempt to make a good impression may fall short when she botches her first assignment. Meanwhile with an ideal marrow donor still to be found, Sara realizes it's time to reach out to the "other woman," Natalie's mother. Brenna eagerly anticipates Greer's return to school, but will she get the happy reunion she's been waiting for?
Guess Who's Coming To Donate Natalie finds out she is a half-match for April; but upon learning what the donation entails, she reconsiders going through with the procedure. Sara's attempts to change her mind only to bring up bitterness over the past. April has to re-earn her boss's trust after screwing up her last interview and reluctantly accepts a soft news assignment to help regain the paper's female readership. Meanwhile, Brenna spends a surprising night out with Natalie, and Beth's relationship with Graham puts her in an awkward position with Dominic.
Cancer Friends With Benefits While April and Leo try chart new relationship waters, April and Dominic spend an incredibly awkward night together covering the same event for the newspaper, and it's clear that the pain of their breakup is still very fresh. With Dominic's heart on his sleeve and not knowing where she stands with Leo, will April be more confused than ever on what to do about either guy? Meanwhile, Natalie and George have some unexpected news for the Carvers.