Karen Sisco premiered on ABC on April 28, 2007, 2003. Smart. Sexy. Tough. Karen Sisco is a United States marshal on Miami's Gold Coast. In pursuit of dangerous fugitives, Karen must pick her way through the dark underbelly of South Beach nightlife and the sunshine and glitz of Palm Beach highlife... while she struggles to win the respect of her supervisor and fellow officers. Karen is a barely concealed weapon who can take down a suspect twice her size. The only man she truly trusts is her father - a retired marshal with a wealth of life experience and street smarts. He's Karen's confidant, counselor, confessor, and her rock when her confidence wavers... which it does every time she tries to connect romantically with a man.